PROPERTIES

assay

98%

form

liquid

refractive index

n20/D 1.4527 (lit.)

bp

50-52 °C/0.6 mmHg (lit.)

density

0.813 g/mL at 25 °C (lit.)

DESCRIPTION

General description

Asymmetric addition of (triisopropylsilyl)acetylene to α,β,γ,δ-unsaturated carbonyl compounds in the presence of a cobalt/Duphos catalyst is reported. A Sonogashira coupling reaction between 1-bromo-3-iodo-5-tertbutylbenzene and (triisopropylsilyl)acetylene is reported.

Application

(Triisopropylsilyl)acetylene may be used as reagent for the rhodium-catalyzed asymmetric alkynylation of various α,β-unsaturated ketones. It may be used as reagent in the enantioselective synthesis of β-alkynylated nitroalkanes.

Packaging